Inhibition of sphingosine-1-phosphate receptor 3 suppresses atp-induced nlrp3 inflammasome activation in macrophages via twik2-mediated potassium efflux

HIGHLIGHTS

  • who: Yingqin Wang and colleagues from the Xiamen University, China have published the paper: Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux, in the Journal: (JOURNAL)
  • what: The authors explored whether the S1P receptors have a regulatory role in NLRP3 inflammasome activation and sepsis. The analysis showed that only the mRNA expression of S1PR3 was upregulated in human monocytes after LPS stimulation (Supplementary Figure 1). Since ATP plays an essential role as an extracellular signaling molecule in the development of sepsis and septic . . .

     

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