Inhibition of the aif/cypa complex protects against intrinsic death pathways induced by oxidative stress

HIGHLIGHTS

• who: N Doti from the InstitutUniversity of, Campus Gro hadern, Max-Lebsche Platz, Munich, Germany have published the paper: Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress, in the Journal: (JOURNAL)
• what: The authors provide evidence that the delivery of the peptide AIF(370-394), corresponding to an amino-acidic region of AIF interacting with CypA, induces neuroprotection by inhibiting the AIF-CypA axis. The authors demonstrate that the glutamate-mediated cell death is exclusively dependent on the interaction between AIF and CypA.
• how: Cell . . .
  

   

  

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