Inhibition of the cardiac fibroblast-enriched histone methyltransferase dot1l prevents cardiac fibrosis and cardiac dysfunction

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• who: Jie Xu from the Permission was obtained from Institutional Animal Care and Use Committee (IACUC), Fudan University, ChinaAll animals and the experimental protocol were completely in accord with the Animal Welfare Act Guide for Use and Care of Laboratory Animals. C BL/, mice (25, g) going through operation were randomly divided into three groups: the sham control group, myocardial infarction group (MI), Dot L inhibitor , group (MI + EPZ5676). Mice in the latter two group were subjected to permanent ligation of the left ascending artery (LAD) to induce myocardial infarction. In brief, mice were anesthetized by isoflurane . . .
  

   

  

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