Inhibition of the ire1/jnk pathway in renal tubular epithelial cells attenuates ferroptosis in acute kidney injury

HIGHLIGHTS

  • who: August and colleagues from the Chongqing Medical University, China have published the research: Inhibition of the IRE1/JNK pathway in renal tubular epithelial cells attenuates ferroptosis in acute kidney injury, in the Journal: (JOURNAL)
  • what: The authors assessed renal function, subcellular morphology, activation of the IRE1/JNK pathway, and the production of reactive oxygen species (ROS) as potential biomarkers of ferroptosis in mice with I/R-induced renal injury and the human renal proximal tubular epithelial_cell line (HK-2 cells) with induced hypoxia/reoxygenation (H/R). The authors found that the Scr and BUN . . .

     

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