Inhibition of the m6a reader igf2bp2 as a strategy against t-cell acute lymphoblastic leukemia

HIGHLIGHTS

• who: Panpan Feng from the (UNIVERSITY) have published the research: Inhibition of the m6A reader IGF2BP2 as a strategy against T-cell acute lymphoblastic leukemia, in the Journal: (JOURNAL) of 24/01/2022
• what: The authors showed that IGF2BP2 was aberrantly upregulated in a subset of human T-ALL and contributed to the survival of T-ALL.
• how: The data showed that the binding activity between IGF2BP2 and the NOTCH1 mRNA fragment was significantly reduced after METTL3 downregulation by lentivirus (Supplementary Fig 7C). Through an analysis of the overlap in the binding peaks . . .
  

   

  

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