Inhibition of the nad salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival

HIGHLIGHTS

  • who: Michael D. Schultz and colleagues from the Department Microbiology, The University Alabama at Birmingham, Birmingham, Alabama, United Ancona, Italy have published the paper: Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival, in the Journal: (JOURNAL) of May/27,/2020
  • what: The authors show that schistosomes appear to lack the enzymes involved in de novo NAD biosynthesis and instead have the capacity to generate extracellular NAM, which the parasites use to produce intracellular NAD via the salvage NAD biosynthetic pathway. The authors show that inhibiting the NAD salvage_pathway in . . .

     

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