Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by cyclin d

HIGHLIGHTS

  • who: Press et al. from the Stem Cell Institute University of, Hinxton, Cambridge , SA, United Kingdom have published the paper: Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D, in the Journal: (JOURNAL)
  • what: The authors demonstrate that cell cycle regulators Cyclin D1-3 control cell fate decisions in human pluripotent stem cells by recruiting transcriptional corepressors and coactivator complexes onto neuroectoderm mesoderm and endoderm genes. To further uncover the mechanisms involving Cyclin Ds in the nucleus, the authors decided to perform a series of functional experiments focusing . . .

     

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