HIGHLIGHTS
SUMMARY
The arterial wall is structurally composed of three layers, starting with the inner layer or tunica intima, which is made up primarily of a monolayer of endothelial cells. Atherosclerotic plaque is formed through the thickening of the tunica intima by proliferating and migrating vSMCs from the tunica media to the tunica intima, followed by accumulation of lipid-laden cells, and other immune cell infiltrates. The tunica media is a secondary location for the extension of atheromatous plaque from the tunica intima, and is not known to be a site for atheroma initiation. Using 25 . . .
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