Insight into the mechanism of dna synthesis by human terminal deoxynucleotidyltransferase

HIGHLIGHTS

  • who: Aleksandra A Kuznetsova and collaborators from the Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, Russia have published the article: Insight into the mechanism of DNA synthesis by human terminal deoxynucleotidyltransferase, in the Journal: (JOURNAL)
  • what: The authors examined pre-steady-state kinetics and MD simulations of nucleotide incorporation by human TdT.

SUMMARY

    It should be noted that the metal ion preference of TdT is not very strict: Mg2+, Mn2+, Zn2+, or Co2+ can bind to the active_site . . .

     

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