HIGHLIGHTS
SUMMARY
Although direct comparison of in_vitro protocols of exercise to different types of in_vivo exercise training is difficult, the authors were able to show that highfrequency, acute EPS (i.e., up to 60 min) simulated some features of a single bout of exercise, whereas low-frequency, chronic EPS (i.e., 2448 h) led to responses known to be mediated by regular exercise in_vivo (Nikolić et_al, 2012). To further elucidate the complexity of exercise response, in_vitro exercise models of electrical pulse stimulation (EPS) have been widely utilized in cultured myotubes to mimic muscle contraction (Aas et_al . . .
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