HIGHLIGHTS
- who: Djemel Hamdane from the Polytechnique, CNRS-INSERM, Palaiseau, France, and 储INSERM, Rue du Général Leclerc have published the paper: Insights into Folate/FAD-dependent tRNA Methyltransferase Mechanism, in the Journal: (JOURNAL) of OCTOBER/21,/2011
- what: Altogether the authors propose a revised for the m5U54 modification catalyzed by TrmFO where Cys-226 attacks the C6 atom of the uridine and Cys-53 plays the role of the general base Instead, the authors show that another conserved cysteine far from the active_site, Cys-226 (equivalent to Cys-223 in TrmFOTT), fulfills this role . . .
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