Insights into non-proteolytic inhibitory mechanisms of polymorphic early-stage amyloid oligomers by insulin degrading enzyme

HIGHLIGHTS

• who: Karina Abramov-Harpaz and Yifat Miller from the Department of Chemistry, Ben-Gurion University of the Negev, POBox, have published the Article: Insights into Non-Proteolytic Inhibitory Mechanisms of Polymorphic Early-Stage Amyloid Oligomers by Insulin Degrading Enzyme, in the Journal: Biomolecules 2022, 1886 of 16/Dec/2022
• what: The aim of this study was to investigate the molecular mechanisms of IDE activity on the encapsulated early-stage Au03b2 dimers: fibril-like and random coil/u03b1-helix dimers. This study provides the inhibition mechanisms of the primary nucleation of Au03b2 aggregation and the basic . . .
  

   

  

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