Insights on cytochrome p450 enzymes and inhibitors obtained through qsar studies

HIGHLIGHTS

• who: Jayalakshmi Sridhar and collaborators from the Department of Chemistry, Xavier University of Louisiana, Drexel Dr, New Orleans, LA, USA have published the research work: Insights on Cytochrome P450 Enzymes and Inhibitors Obtained Through QSAR Studies, in the Journal: Molecules 2012, 17, 9283-9305 of 29/06/2012
• what: The QSAR efforts in the second approach aim toward improving the efficacy of the inhibitors/substrates of the individual CYPs through knowledge-based design. This model showed a clear dependency of the inhibition potency on the electrostatic interactions. The model showed the region of aromatic interaction . . .
  

   

  

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