Instability mechanism of osimertinib in plasma and a solving strategy in the pharmacokinetics study

HIGHLIGHTS

  • who: METHODS et al. from the University of Trieste, Italy have published the research work: Instability Mechanism of Osimertinib in Plasma and a Solving Strategy in the Pharmacokinetics Study, in the Journal: (JOURNAL)
  • what: This study seeks to understand and explain that cysteine`s potential role in plasma may affect the stability of osimertinib, AZ-5104, and AZ-7550 during the storage of plasma samples at room or higher temperatures. Stability of Osimertinib/AZ-5104/AZ-7550 To test the contribution of plasma_protein in the instability of osimertinib, AZ-5104, and AZ-7550, rat plasma . . .

     

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