HIGHLIGHTS
- who: Qutuba G. Karwi from the Research Centre, University of Alberta, Heritage Medical Research Centre, Edmonton, AB T G , Canada have published the research work: Insulin directly stimulates mitochondrial glucose oxidation in the heart, in the Journal: (JOURNAL)
- what: The authors show that insulin-stimulated phosphorylation of mitochondrial Akt is a prerequisite for transducing insulin's direct stimulation of glucose oxidation. The authors showed that insulin stimulates the phosphorylation of mitochondrial Akt, and that this is associated with increased activity of the PDH complex. Taken together, the authors propose that PKC-δ has an inhibitory effect . . .
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