HIGHLIGHTS
- who: . and colleagues from the Nantong University, China have published the article: Integrated bioinformatics, network pharmacology, and arti cial intelligence to predict the mechanism of celastrol against muscle atrophy caused by colorectal cancer, in the Journal: (JOURNAL)
- what: In this study, blood exosome data from colorectal cancer were used to analyze differentially expressed (DE) miRNAs, and then, DE mRNAs were analyzed in muscle atrophy samples to model the miRNAu2012mRNA regulatory network and to analyze the potential network targets of celastrol for the treatment of colorectal cancer-related muscle atrophy based on network pharmacology using AlphaFold2 . . .
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