Integrated cellular 4d-tims lipidomics and transcriptomics for characterization of anti-inflammatory and anti-atherosclerotic phenotype of myd88-ko macrophages

HIGHLIGHTS

• What: Specifically, the authors aimed to uncover potential molecular mechanisms and fingerprints related to atherosclerosis protection of MYD 88 deficient macrophages. The authors set out to characterize in-depth how the lipid composition changes and which lipid pathways are effected in macrophages upon acquiring an anti-inflammatory phenotype Frontiers in Cell and Developmental Biology The primary focus was to assess the suitability of extraction procedure for 4D-TIMS cellular lipidomics and metabolomics using a population of 1 million HEK293 cells, with emphasis on lipid and metabolite coverage as well as lipid quantification. The analysis reveals that a . . .
  

   

  

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