Integrated single-cell (phospho-)protein and rna detection uncovers phenotypic characteristics and active signal transduction of human antibody secreting cells

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  • who: Erik van Buijtenen from the Aduro Biotech, Oss , AB, the Netherlands Institute for Molecules and Materials, Radboud University, Nijmegen , AJ, the Netherlands have published the Article: Integrated single-cell (phospho-)protein and RNA detection uncovers phenotypic characteristics and active signal transduction of human antibody secreting cells, in the Journal: (JOURNAL)
  • how: The approach detected differential expression of plasmablast and plasma cell markers homing receptors and TNF receptors. addition differential sensitivity was observed for the different cytokine stimulations that were applied during vitro differentiation. The authors analysed the datasets using multi-omics factor analysis (MOFA . . .

     

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