Integration-independent transgenic huntington disease fragment mouse models reveal distinct phenotypes and life span in vivo*

HIGHLIGHTS

• who: Robert O'Brien from the (UNIVERSITY) have published the article: Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo*, in the Journal: (JOURNAL) of July/31,/2015
• what: The authors focused on comparison of the N552-Q148 and N586Q148 transgenic mice because although the observed differences in motor, life span, and behavioral phenotypes are distinct, they differ in length by only 34 amino_acids and because they represent caspase cleavage products that have been implicated as highly significant in HD disease progression and pathology . The majority of the . . .
  

   

  

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