HIGHLIGHTS
- who: Gloriia Novikova from the Department University of of Medicine, Indianapolis, IN, USA have published the research: Integration of Alzheimer⠒s disease genetics and myeloid genomics identifies disease risk regulatory elements and genes, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 16/09/2020
- what: The authors show that AD risk alleles are specifically enriched in active enhancers of monocytes, macrophages and microglia and identify transcription factor binding motifs (TFBMs) overrepresented within these regulatory elements. The authors report an integration of AD GWAS with epigenomic and transcriptomic datasets from myeloid cells to nominate candidate causal . . .
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