Integrative analysis reveals novel insights into juvenile idiopathic arthritis pathogenesis and shared molecular pathways with associated traits

HIGHLIGHTS

• What: While previous GWAS findings have shown that variants within this locus are associated with JIA (Hinks et_al, 2013; López-Isac et_al, 2021), the study provides evidence for the causal impact of altered gene_expression within this locus. The authors propose that downregulation of LTB may allow for more LTα proteins to exist in a soluble form (i.e., not associated with membrane-bound LTβ). The authors propose that causal genes regulated across multiple immune cell types could contribute to JIA by influencing patients` systemic inflammation profiles. The authors propose that the protein-protein interactions the authors . . .
  

   

  

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