Integrative genomic and transcriptomic analyses illuminate the ontology of her2-low breast carcinomas

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SUMMARY

    Conversely, since for gene_expression analysis the authors used a NanoString approach that is not been widely adopted, the authors profiled a series of HER2-negative (n=30) and HER2positive (n=15) BCs selected from the archives and collected in the frame of the "Profiling" protocol quoted above for HLBCs (Fig 1C and Additional file 1: Supplementary Methods). Targeted gene_expression profiling RNA-targeted gene_expression profiling (tGEP) was carried out on 91 HLBCs, 30 HER2-negative, and 15 HER2-positive samples using the BreastCancer 360™ Panel (NanoString Technologies, Seattle, USA, 776 BCrelated genes), following the manufacturer . . .

     

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