HIGHLIGHTS
SUMMARY
In the early 1990s, I posed a hypothesis: "Is it possible to create an illustration of a living cell that shows all macromolecules, drawn to scale and integrating available structural and biophysical information?" My most recent E. coli illustration (doi: 10.2210/rcsb_pdb/goodsell-gallery-028) is now based on a genome, a proteome with abundances, and a flood of new structural information from the revolution in cryoelectron microscopy. The JCVI-syn3A cell provides a unique opportunity: to create an illustration that depicts an entire proteome of a living cell. Ribosomes in multiple states . . .
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