Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling

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  • who: Nirmala Arul Rayan from the Animal housing and treatment All procedures were performed in accordance with the guidelines established by the Canadian Council on Animal Care with protocols approved by the McGill University Facility Animal Care CommitteeLong-Evans rats were purchased from Charles River (RRID:RGD_2308852) and bred at the Douglas Mental Health University Institute animal facility., day old uncharacterised male rats were housed in pairs and separated as control (Sham) group and fluoxetine-treated (FT) group. Fluoxetine (, mg/kg/day) was provided ad libitum in the drinking water and this formed the treatment group, while . . .

     

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