Integrative network analysis interweaves the missing links in cardiomyopathy diseasome

HIGHLIGHTS

SUMMARY

    Genetic connectivity of cardiomyopathy genes with other pathophysiological diseases. The authors extracted a non-redundant set of 4406 disease phenotypes and associated genes in this process. Each disease was partitioned into disease-category after merging similar diseases using fuzzy matching. ultimately reducing the size to 2722 distinct disease-gene associations (see Supplementary Table S1). Next, to construct cardiomyopathy-centric diseasome, the authors investigated only those disease-gene associations that consisted of at least one cardiomyopathy gene (see Supplementary Table S2). Ultimately, this bipartite network was projected to the disease network based on common genes . . .

     

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