Inter-ligand std nmr: an efficient 1d nmr approach to probe relative orientation of ligands in a multi-subsite protein binding pocket

HIGHLIGHTS

• who: Serena Monaco and collaborators from the School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich , TJ, UK have published the article: Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket, in the Journal: Pharmaceuticals 2022, 1030 of /2022/
• what: The authors report hereby for the first time the proof-of-concept that Inter-Ligand saturation transfer NMR (IL-STD NMR) is technically feasible to probe inter-ligand proximity between bound ligands in adjacent binding_sites of a given protein.
 



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