Interaction-based mendelian randomization with measured and unmeasured gene-by-covariate interactions

HIGHLIGHTS

  • who: Wes Spiller and collaborators from the Population Health Sciences, University of Bristol, Bristol, United Kingdom, Postgraduate Program in have published the Article: Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions, in the Journal: PLOS ONE of March/10,/2022
  • what: The authors explore the effect of body mass index (BMI) upon systolic blood pressure (SBP) using data from the UK Biobank finding evidence of a positive effect of BMI on SBP. Specifically, the authors focus upon the application of MR-GENIUS in the absence of a pre-defined interaction covariate . . .

     

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