Interaction between glycolysis‒cholesterol synthesis axis and tumor microenvironment reveal that gamma-glutamyl hydrolase suppresses glycolysis in colon cancer

HIGHLIGHTS

• who: Yan-Jie Chen and collaborators from the Geneis CoLtd, China Tianjin University of Traditional have published the research work: Interaction between glycolysisu2012cholesterol synthesis axis and tumor microenvironment reveal that gamma-glutamyl hydrolase suppresses glycolysis in colon cancer, in the Journal: (JOURNAL)
• what: The authors evaluated the prognostic value of KRAS mutations and identified key genes involved in glycolysis.
• how: Clinical data were analyzed using the chi-squared test. The GSEA results showed that specific metabolism-related pathways were enriched . GGH overexpression decreased the extracellular lactate content and intracellular ATP levels in cells . . .
  

   

  

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