Interdomain communication in dna topoisomerase ii

HIGHLIGHTS

• who: Felix Mueller-Planitz from the Felix Mueller-Planitz and Daniel Herschlag, From the Department of Biochemistry, School of Medicine, Stanford University, Stanford, California, Topoisomerase II catalyzes the ATP-dependent transport of a DNA segment (T-DNA) through a transient double strand break in another DNA segment (G-DNA)A fundamental mechanistic question is how the individual steps in this process are coordinated. We probed communication between the DNA binding sites and the individual enzymatic activities, ATP hydrolysis, and DNA cleavage. We employed short DNA duplexes to control occupancy at the two binding sites of wild-type . . .
  

   

  

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