HIGHLIGHTS
- who: Rheumatoid arthritis et al. from the Newcastle University, Newcastle Results We reproduced our previous findings have published the Article: Interferon-u03b1-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming, in the Journal: (JOURNAL) of 16/02/2022
- what: The authors demonstrate that IFN-u00adalpha levels are transiently elevated in some early RA patients and are responsible for generating the IGS. u21d2 Autoantibodies predate clinical presentation, and the authors demonstrate a clear association between IFN-u03b1 and RF titres in eRA consistent with previous observations in autoimmunity.12 17 Altered DNA methylation regulates . . .
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