Interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms favorably impacts deregulation of oxidative stress genes and antioxidative defense mechanisms

HIGHLIGHTS

  • who: Vibe Skov and colleagues from the Department of Hematology, Zealand University Hospital, Roskilde, Denmark, Department of Clinical have published the research: Interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms favorably impacts deregulation of oxidative stress genes and antioxidative defense mechanisms, in the Journal: PLOS ONE of 14/06/2022
  • what: The authors report the first gene expression profiling study on the impact of rIFNu03b1 upon oxidative stress and antioxidative defense genes in patients with MPNs (n = 33) showing that rIFNu03b1 downregulates several upregulated oxidative stress genes and upregulates downregulated antioxidative defense . . .

     

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