Interleukin-15 and chemokine ligand 19 enhance cytotoxic effects of chimeric antigen receptor t cells using zebrafish xenograft model of gastric cancer

HIGHLIGHTS

  • who: Zhifeng Zhou et al. from the San Martino Hospital (IRCCS), Italy Johannes Gutenberg University Mainz have published the article: Interleukin-15 and chemokine ligand 19 enhance cytotoxic effects of chimeric antigen receptor T cells using zebrafish xenograft model of gastric cancer, in the Journal: (JOURNAL)
  • what: In the current study, IL-15 was introduced to NKG2D CAR T_cells, and the resulting 15u00d719 CAR T_cells secreted high levels of IL-15 and massively expanded upon stimulation by tumor antigens. The results of this study demonstrated that the introduction of IL-15 and CCL19 into conventional . . .

     

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