Interleukin-22 protects from endotoxemia by inducing suppressive f4/80

HIGHLIGHTS

• who: Chang Yu from the Male C BL/, mice (, weeks old) were purchased from Shanghai Model Organisms CenterThe care and use of the mice were all approved by the Ethics committee of the Shanghai University of Chinese Traditional Medicine. , is a recombinant fusion protein consisting of two human interleukin, (IL-22) molecules linked to an immunoglobulin constant region (IgG2-Fc). This , was provided by Evive Biotechnology (Shanghai) Ltd. In LPS-induced endotoxemia model, sublethal dose (, mg/ kg) or lethal dose (, mg/kg) LPS (Sigma) and , mg/kg , were i.p. injected into mice. Isolation of peritoneal macrophages . . .
  

   

  

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