HIGHLIGHTS
SUMMARY
Multiple cytokines have been studied for their role in the propagation of the inflammatory process related to inflammatory bowel diseases (IBD), but the role of interleukin-4 remains controversial. A group of 160 patients with IBD (86CD/74UC) and 160 healthy controls were genotyped for IL-4 rs2243250/-590C/T and rs2070874/-34C/T using real-time polymerase_chain_reaction with TaqMan assay. The hypothesis regarding the disease`s pathogenic mechanism implies exposure to environmental factors and dysbiosis as determinants of abnormal immune_response in a genetically predisposed host. Patients carrying predisposition alleles to IBD manifest a . . .
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