HIGHLIGHTS
- who: Li Xiao from the Department of Stomatology, Sichuan Provincial Peopleu2019s Hospital, University China have published the article: Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway, in the Journal: (JOURNAL)
- what: The authors proved that JAK2 inhibitor (Fedratinib) and STAT3 inhibitor (Protosappanin A) could notably attenuate the induction of IL-6 on the proliferation and inflammation of OCSS cells. thus, the authors demonstrated that IL-6 could accelerate OSCC progression by JAK2 and STAT3 pathway. This study demonstrated that IL-6, as an oncogene, is . . .
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