Internal modifications in the cenp-a nucleosome modulate centromeric dynamics

HIGHLIGHTS

• who: Minh Bui from the Abbreviations ChIP: chromatin immunoprecipitation have published the Article: Internal modifications in the CENP-A nucleosome modulate centromeric dynamics, in the Journal: (JOURNAL)
• what: The authors provide evidence implicating the histone acetyltrans‑ ferase (HAT) p300 in this cycle.
• how: Four systems were simulated using all-atom MD the CENPA NCP the acetyl CENP-A NCP (CENP-A K124ac and H4K79ac) the CENP-A NCP bound to the kinetochore protein CENP-C and_(4) the acetyl CENP-A NCP bound to CENP-C. The authors studied the change in DNA . . .
  

   

  

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