HIGHLIGHTS
- who: from the TARGETED REGULATION OF CGRP GENE EXPRESSION AF. Russo and P.L. Durham Department of Physiology and Biophysics, University of Iowa, Iowa City, IA , The neuropeptide calcitonin gene-related peptide (CGRP) is a potent regulator of cerebral vascular tone and contributes to neurogenic inflammation. Clinical studies have shown that CGRP levels are elevated during the painful phase of migraine headache, then restored to baseline by antimigraine, drugs. Conversely, CGRP is depleted in perivascular nerve terminals from patients who have suffered vasospasm following subarachnoid hemorrhage. We have investigated the mechanisms controlling CGRP expression in the trigeminal . . .
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