HIGHLIGHTS
SUMMARY
In this context, however, not only vitamin D level, but the dynamic interaction between the parathyroid gland, kidney, bone, vitamin D metabolites, vitamin D-binding protein (DBP), SIRT1Axl, and miR-34a level are all important. CYP24A1 mitochondrial protein expression, which determines the half-life of 1,25(OH2 )D3, is regulated both by its methylation status and by vitamin D. Its inhibition facilitates the antiproliferative effect of vitamin D on the downregulation of the WNT/β-catenin pathway and on the inhibition of targeted genes, e_g, c-Myc, TCF1, and LEF1. In a ligand-dependent . . .
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