Intersection of tks5 and fgd1/cdc42 signaling cascades directs the formation of invadopodia

HIGHLIGHTS

• who: Florent Dingli et al. from the (UNIVERSITY) have published the article: Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia, in the Journal: (JOURNAL) of 07/09/2022
• what: The authors show that TKS5 is required for the assembly and matrix-degradative function of elongated F-actin/cortactinpositive invadopodia forming in association with type I collagen fibers. The authors show that the carboxy-terminal region of TKS5 (aa 505-1118), encompassing two of five SH3 domains (SH3#4 and SH3#5), interacts with the amino-terminal proline-rich domain Journal . . .
  

   

  

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