Intestinal alkaline phosphatase prevents sulfate reducing bacteria-induced increased tight junction permeability by inhibiting snail pathway

HIGHLIGHTS

• who: Sudha B. Singh from the l`Inflammation (INSERM), France Peking University, China have published the Article: Intestinal Alkaline Phosphatase Prevents Sulfate Reducing Bacteria-Induced Increased Tight Junction Permeability by Inhibiting Snail Pathway, in the Journal: (JOURNAL)
• what: The authors report that Desulfovibrio vulgaris (DSV) induced increased barrier permeability in polarized Caco-2 cells. The study demonstrates that DSV induced a loss of epithelial barrier integrity and caused an aberrant localization of TJ protein occludin in a snail-dependent manner.
• how: Cells with TEER >450 W were used in the experiments.
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