HIGHLIGHTS
- who: Charles Roquetaillade from the (UNIVERSITY) have published the Article: Intracellular calcium signaling and phospho-antigen measurements reveal functional proximal TCR activation in lymphocytes from septic shock patients, in the Journal: (JOURNAL)
- what: The authors show that immediate signaling downstream TCR stimulation was not altered in circulating CD4 lymphocytes from septic shock patients.
SUMMARY
Septic patients develop marked T lymphocyte dysfunctions such as profound lymphopenia, increased expression of inhibitory co-receptor molecules, decreased repertoire diversity, and reduced functionality (proliferation and cytokine production). For instance, while the role of deactivated mTORC1 is . . .
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