HIGHLIGHTS
- who: Yunash Maharjan from the Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea have published the paper: Intracellular cholesterol transport inhibition Impairs autophagy flux by decreasing autophagosome-lysosome fusion, in the Journal: (JOURNAL)
- what: This study compared the effect of autophagy inhibitors, including chloroquine, bafilomycin A1 and U18666A, on autophagy flux and cholesterol accumulation. Taken together, the authors propose that lysosomal acidification and cholesterol accumulation are independent in the processes of autophagy.
- how: The results showed that filipin-positive lysotracker puncta increased after 4 h . . .
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