Intracellular prostaglandin e2 contributes to hypoxia-induced proximal tubular cell death

HIGHLIGHTS

• who: Coral Garcu00eda-Pastor from the Departamento de Biologu00edaUniversidad de Alcalu00e1 have published the research work: Intracellular prostaglandin E2 contributes to hypoxia-induced proximal tubular cell death, in the Journal: Scientific Reports Scientific Reports
• how: The results indicated that hypoxia determined in a transient manner transcriptional up-regulation of COX-2 expression (Fig 3ab) and that COX-2 inhibition blunted the increase in iu00ad PGE2 in HK-2 cells under hypoxia (Fig 3c). Although the consequences of the activation of HIF-1u03b1 on hypoxia-induced apoptosis are controversial (probably because they may be context-dependent37 . . .
  

   

  

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