HIGHLIGHTS
- who: Tobias Kammann and collaborators from the Center for Sepsis Control and Care, Jena University Hospital, Am Klinikum, Jena, Germany have published the paper: Intracellularly Released Cholesterol from Polymer-Based Delivery Systems Alters Cellular Responses to Pneumolysin and Promotes Cell Survival, in the Journal: Metabolites 2021, 821 of /2021/
- what: PLY impedes sterol biosynthesis in affected cells.
- how: The authors thus decided to investigate cellular defense mechanisms against PLY in the presence of polymer-based particles of different sizes and compositions prepared by nano- (NP) or microprecipitation (MP) increasing intracellular cholesterol. The mean . . .
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