HIGHLIGHTS
- who: Lung transplantation and collaborators from the Faculty of Medicine, UK have published the research work: Intravascular donor monocytes play a central role in lung transplant ischaemia-reperfusion injury, in the Journal: (JOURNAL)
- what: The authors demonstrate, for the first time, that intravascular monocytes retained in an IPL model become activated and contribute significantly to the development of I/R lung injury.
- how: The authors investigated this hypothesis using a mouse isolated perfused lung (IPL) model of transplant-related early I/R injury combined with intravascular monocyte depletion and repletion treatments.
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