Intravenous transplantation of apoptosis repressor with caspase recruitment domain-overexpressing mesenchymal stem cells promotes bone formation in bisphosphonate-related osteonecrosis of the jaw rats

HIGHLIGHTS

• What: The authors aimed to investigate whether transplantation of ARCoverexpressing BMSCs had a therapeutic effect on BRONJ and explored possible mechanisms. The authors established ARC-overexpressing BMSCs to comprehensively evaluate its therapeutic effect on BRONJ jaw-derived BMSCs in_vitro, as well as BRONJ rats in_vivo.
• Who: louis from the Department of Prosthodontics, Ninth People`s Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Zhizaoju Road, Shanghai, China have published the Article: Regenerative Medicine and Dentistry, in the Journal: (JOURNAL)
• How: These data indicated that the secretion level of TNF-α was significantly . . .
  

   

  

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