HIGHLIGHTS
- who: Marina Alexeeva1 from the University of Texas Health Science Center at San Antonio, United States have published the paper: Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification, in the Journal: (JOURNAL)
- what: In this report the authors demonstrate that hUNG-hitherto regarded as a mono-functional DNA glycosylase-is able to incise the phosphodiester backbone of DNA at the uracil site after uracil excision . The authors propose, based on the inconclusive data on the precise role of APE1 in CSR, and on the demonstration of U-DNA . . .
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