Introduction

HIGHLIGHTS

• who: Camptothecin prodrug et al. from the Camptothecin (CPT), first isolated from the Chinese tree Camptotheca acuminata, was widely used in preclinical or clinical anti-cancer therapy, including lung, colon, and breast cancer, as the topoisomerase I inhibitor [1, ]However, poor water solubility and the instability of lactone ring in the physiological environment limit the therapy efficacy of CPT [3-5]. Another bottleneck in the application of CPT is the high-dose requirement and systemic toxicity due to its non-specificity. Tumor-specific delivery, including delivery to tumor tissues, tumor microenvironment, cells, and subcellular organelles (mitochondria, lysosome . . .
  

   

  

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