Intronic enhancer is essential for nr5a1 expression in the pituitary gonadotrope and for postnatal development of male reproductive organs in a mouse model

HIGHLIGHTS

• who: Yuichi Shima and collaborators from the Division of Microscopic and Developmental Anatomy, Department of Anatomy, Kurume University School of Medicine, Asahi-machi, Kurume, Fukuoka, Japan have published the article: Intronic Enhancer Is Essential for Nr5a1 Expression in the Pituitary Gonadotrope and for Postnatal Development of Male Reproductive Organs in a Mouse Model, in the Journal: (JOURNAL) of 19/Dec/2022
• what: The authors demonstrated that deletion of this PE leads to cell-specific and complete NR5A1 deficiency.
• how: By comparing the pit_m_homo_down and gonadotrope_m_up gene identified 16 genes with gonadotrope-specific NR5A1 . . .
  

   

  

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