HIGHLIGHTS
- What: The authors analyzed the relationship between dosage-sensitive transcription factors and their targets which illustrated the modulations and indicates genomic imbalance is related to stoichiometric changes in components of gene regulatory complexes.In summary this study shows the existence of trans-acting effects and compensation mechanisms in human aneuploidies and contributes to the understanding of gene expression regulation in unbalanced genomes and disease states.
- Who: Shuai Zhang and collaborators from the Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, China have published the paper: Inverse . . .
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